Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers

S Padmanabhan; R C Lavin; P M Thakker; J Guo; L Zhang; D Moore; M E Perlman; C Kirk; D Daly; K J Burke-Howie; T Wolcott; S Chari; D Berlove; J B Fischer; W F Holt; G J Durant; R N McBurney

doi:10.1016/s0960-894x(01)00644-8

Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers

Bioorg Med Chem Lett. 2001 Dec 17;11(24):3151-5. doi: 10.1016/s0960-894x(01)00644-8.

Authors

S Padmanabhan¹, R C Lavin, P M Thakker, J Guo, L Zhang, D Moore, M E Perlman, C Kirk, D Daly, K J Burke-Howie, T Wolcott, S Chari, D Berlove, J B Fischer, W F Holt, G J Durant, R N McBurney

Affiliation

¹ CeNeS Pharmaceuticals Inc., 333 Providence Highway, Norwood, MA 02062, USA. padman12@hotmail.com

PMID: 11720863
DOI: 10.1016/s0960-894x(01)00644-8

Abstract

Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described.

MeSH terms

Animals
Drug Evaluation, Preclinical
Guanidine / analogs & derivatives*
Guanidine / chemical synthesis*
Guanidine / pharmacology*
Mice
Mice, Inbred DBA
Sodium Channel Blockers*

Substances

Sodium Channel Blockers
Guanidine